Moxonidine Therapy Considerations

Contraindications and Warnings

• Moxonidine is contraindicated in patients with heart failure with reduced ejection fraction (HFrEF) due to increased mortality risk 1, 2, 4
• The European Society of Cardiology guidelines recommend against using moxonidine to reduce blood pressure in HFrEF patients (Class III recommendation, Level of Evidence B) 1

Safety and Adverse Effects

• Moxonidine may precipitate or exacerbate depression, bradycardia, and orthostatic hypotension 3
• Sudden cessation of treatment can produce a withdrawal syndrome 3

Place in Therapy

• Moxonidine is generally considered a second or third-line antihypertensive agent 3, 5

Monitoring

• Blood pressure should be regularly monitored during treatment 3
• Patients should be assessed for signs of depression, bradycardia, and orthostatic hypotension 3
• Caution is advised when discontinuing therapy to avoid withdrawal symptoms 3