Sertraline Dosing Considerations

Special Population Considerations

• The 25 mg dose may be particularly valuable for patients who are more sensitive to medication side effects or who are taking multiple medications 1

Common Pitfalls and Caveats

• Sertraline should not be discontinued abruptly; gradual tapering over 10-14 days helps limit withdrawal symptoms 2
• When both sertraline and cholestyramine are used, they should be spaced a minimum of four hours apart to prevent binding and loss of efficacy 3
• Patients should be monitored closely for clinical worsening, suicidality, and unusual behavior changes, especially during the initial few months of therapy or at times of dose changes 1