Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/23/2025

Olanzapine Overdose Management

Management of Specific Complications

  • The American College of Medical Toxicology recommends considering low-dose benzodiazepines with caution for agitation in olanzapine overdose, as fatalities have been reported with concurrent use of benzodiazepines with high-dose olanzapine 1, 2