Carvedilol Dosing Guidelines

Dosing Recommendations

• The American College of Cardiology recommends a target dose of 25 mg twice daily (50 mg total daily) for patients with Heart Failure with Reduced Ejection Fraction (HFrEF) weighing over 85 kg, with a starting dose of 3.125 mg twice daily and titration every 1-2 weeks if tolerated 1
• The American College of Cardiology and American Heart Association guidelines suggest a dosing regimen for angina of 6.25 mg twice daily, uptitrated to a maximum of 25 mg twice daily, aligning with the maximum total daily dose of 50 mg 2, 3
• Abrupt discontinuation of carvedilol should be avoided as it can precipitate rebound hypertension or worsening heart failure, according to the American College of Cardiology 1

Formulation-Specific Guidelines

• The controlled-release formulation (Coreg CR) has a maximum dose of 80 mg once daily, distinct from immediate-release carvedilol, as recommended by the American College of Cardiology 1, 4