Ondansetron-Induced Liver Enzyme Elevation

Medication Review and Hepatotoxicity Potential

• Gabapentin is generally not associated with significant hepatotoxicity in the reviewed evidence, according to The Lancet Gastroenterology and Hepatology 1
• Promethazine is not specifically identified as causing significant AST elevations in the reviewed evidence, as reported by The Lancet Gastroenterology and Hepatology 1

Diagnostic Approach

• Muscle injury can elevate AST more than ALT, as noted in the Journal of Autoimmunity 2

Important Caveats

• Patients with pre-existing liver disease may be at higher risk for medication-induced liver enzyme elevations, as stated in The Lancet Gastroenterology and Hepatology 1
• Concomitant use of multiple potentially hepatotoxic medications can increase the risk of liver enzyme elevations, according to The Lancet Gastroenterology and Hepatology 1