Spinal Cord Stimulation for Peripheral Neuropathy

First-Line Treatment Options for Peripheral Neuropathy

The American Diabetes Association recommends tricyclic antidepressants (TCAs) such as nortriptyline or desipramine as first-line pharmacological treatments for peripheral neuropathy, with evidence showing efficacy 1, 2
The American Diabetes Association also recommends serotonin-norepinephrine reuptake inhibitors (SNRIs), particularly duloxetine, and α-δ agonists including pregabalin or gabapentin as first-line treatments for peripheral neuropathy, with consideration of comorbidities and potential side effects 1, 2

The Mayo Clinic recommends considering spinal cord stimulation (SCS) when patients have failed first-line pharmacological treatments, with a significant impact on quality of life 3, 1

The American Diabetes Association suggests that SCS should be considered as part of a comprehensive approach that may still include adjunctive pharmacological treatments, with careful consideration of the risk/benefit ratio 1, 2