Amoxicillin/Clavulanate Dosing Recommendations

Evidence for TID Dosing

Amoxicillin/clavulanate 625 mg (500/125 mg) three times daily is a standard dosing regimen that has been used in multiple clinical trials for various infections, particularly for respiratory tract infections 1
The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 specifically mentions amoxicillin/clavulanate 625 mg three times daily for 14 days as an established treatment regimen for sinusitis 2, 1
In a randomized clinical trial comparing different antibiotic regimens for chronic rhinosinusitis, amoxicillin/clavulanate 625 mg three times daily for 14 days was used as a standard treatment arm 1

For respiratory tract infections such as sinusitis, the 500/125 mg TID regimen has shown clinical efficacy 1
For chronic rhinosinusitis, amoxicillin/clavulanate 625 mg three times daily for 14 days has demonstrated clinical improvement and bacteriologic eradication comparable to other antibiotic regimens 1
In a comparative study for acute maxillary sinusitis, amoxicillin/clavulanate 500 mg three times daily for 9 days showed similar clinical cure rates to ciprofloxacin (58.6% vs. 51.2%) 1

Amoxicillin/clavulanate 500/125 mg three times daily is an appropriate dosing regimen supported by clinical evidence and guidelines, particularly for respiratory tract infections such as sinusitis 2, 1

The British Thoracic Society recommends Amoxicillin-clavulanate 625 mg (500/125 mg) three times daily as the established standard dosing for respiratory infections 3
The Infectious Diseases Society of America recommends Amoxicillin-clavulanate 875/125 mg twice daily as the appropriate twice-daily formulation 4
The standard duration for most respiratory infections is 14 days, as recommended by the British Thoracic Society and the Infectious Diseases Society of America 3, 4

For Acute Bacterial Rhinosinusitis, the first choice is Amoxicillin-clavulanate 875/125 mg twice daily for 5-7 days (adults) or 10-14 days (children), as recommended by the Infectious Diseases Society of America 4
For Bronchiectasis Exacerbations, the British Thoracic Society recommends Amoxicillin-clavulanate 625 mg (one tablet) three times daily for 14 days 3