Management of Severe Hyperkalemia with Lokelma

Acute Management

• For severe hyperkalemia (≥6.0 mEq/L), significant reductions in serum potassium levels were observed within 1 hour of a single 10 g dose, as reported by the Mayo Clinic Proceedings 1
• For patients with severe hyperkalemia (K+ 6.9), consider additional acute interventions alongside Lokelma, such as insulin plus glucose, which may provide more rapid potassium lowering, according to the Mayo Clinic Proceedings 2

Monitoring and Maintenance

• Monitor serum potassium levels closely during the initial treatment phase, ideally within the first few hours of administration and then daily until stabilized, as recommended by the Mayo Clinic Proceedings 3

Lokelma Dosing and Management for Hyperkalemia

Medication Management and Considerations

• The American College of Cardiology recommends reviewing and potentially adjusting RAAS inhibitors, such as ACE inhibitors, ARBs, and aldosterone antagonists, rather than discontinuing them, as potassium binders like Lokelma may facilitate continuation of these cardioprotective medications 4