Treatment Protocol for Post-Inflammatory Hyperpigmentation After Injections

Initial Management Strategy

• The American Academy of Dermatology recommends considering low-to-moderate potency topical corticosteroids if residual inflammation is present at injection sites, though use judiciously to avoid additional pigmentary changes 1, 2

First-Line Topical Therapy

• The American Academy of Dermatology suggests using topical retinoids (tretinoin, adapalene, or tazarotene) to enhance epidermal turnover and pigment dispersion, with a strength of evidence based on high-quality studies 3

Common Pitfalls to Avoid

• The American Academy of Dermatology advises against relying on topical corticosteroids alone for PIH treatment, as they may help with inflammation but are not depigmenting agents, with a recommendation based on moderate-quality evidence 1, 4