Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/27/2025

Metronidazole-Induced Seizure Risk

Introduction to Metronidazole-Induced Seizures

  • Metronidazole may reduce seizure threshold and is contraindicated in patients with a history of seizures, according to the World Journal of Emergency Surgery guidelines 1

Clinical Considerations for Metronidazole Use

  • Similar to tramadol, metronidazole may reduce seizure threshold and is contraindicated in patients with a history of seizures, as recommended by the World Journal of Emergency Surgery 1

REFERENCES

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