Tapering Protocol for Mirtazapine

Adjusting the Taper if Needed

• If withdrawal symptoms become severe during the tapering process, consider slowing the taper by extending the time between dose reductions, temporarily returning to the previous well-tolerated dose before attempting a slower taper, or using an even slower taper for patients who have been on mirtazapine for years, as recommended by the American Academy of Family Physicians 1
• Consider timing the final discontinuation when the patient has fewer life stressors or demands, as this may improve tolerability, according to the American Academy of Family Physicians 1
• Don't set arbitrary time limits for completing the taper; individualize based on patient response, as suggested by the American Academy of Family Physicians 1