Echogenic Fetal Kidneys: Causes and Clinical Implications

Genetic and Chromosomal Abnormalities

• Aneuploidy, particularly trisomy 21, but also trisomy 18, trisomy 13, and monosomy X, can present with echogenic kidneys, according to the American College of Obstetricians and Gynecologists 1
• Tuberous sclerosis with renal involvement can also cause echogenic kidneys, as reported by the American College of Obstetricians and Gynecologists 2

Infectious Causes

• Congenital cytomegalovirus (CMV) infection, toxoplasmosis, and other TORCH infections (rubella, herpes, varicella, parvovirus) can be associated with echogenic fetal kidneys, as noted by the American College of Obstetricians and Gynecologists 1

Clinical Implications

• Karyotype analysis should be considered, especially with other soft markers or abnormalities, as recommended by the American College of Obstetricians and Gynecologists 1
• Screening for congenital infections may be warranted, according to the American College of Obstetricians and Gynecologists 1
• Genetic evaluation should be considered when appropriate, as suggested by the American College of Obstetricians and Gynecologists 1