Aspirin Use in Patients with Camphor-Menthol-Methyl Salicylate Allergy

Introduction to Aspirin and Camphor-Menthol-Methyl Salicylate Allergy

• The American Academy of Allergy, Asthma, and Immunology suggests that patients with a history of contact dermatitis to camphor-menthol-methyl salicylate products can safely take aspirin, as the mechanisms of action are different 1, 3

Diagnosis and Evaluation

• The Journal of Allergy and Clinical Immunology recommends that patients with a history of systemic symptoms after topical application of camphor-menthol-methyl salicylate products should consult an allergist before taking aspirin to determine if systemic absorption occurred 3, 5
• Patients with severe skin reactions, such as blistering or extensive rash, should also be evaluated by an allergist before taking aspirin 4, 6

Treatment and Management

• The American College of Allergy, Asthma, and Immunology states that aspirin can be taken safely by patients with only topical contact reactions to camphor-menthol-methyl salicylate products, as the mechanism differs entirely from systemic NSAID hypersensitivity 3
• A supervised 2-step aspirin challenge may be considered if there is clinical uncertainty about true hypersensitivity 4

Warning Signs and Contraindications

• The American Academy of Allergy, Asthma, and Immunology warns that patients with a history of asthma or nasal polyps with any NSAID reaction, respiratory distress after any NSAID exposure, or severe cutaneous reactions should be evaluated by an allergist before taking aspirin 3, 5, 6