Apomorphine for Sexual Enhancement

Evidence on Apomorphine for Sexual Function

The American College of Physicians recommends against using apomorphine for enhancing sexual experience due to its limited efficacy and significant side effects 1
Sildenafil, a PDE-5 inhibitor, has been shown to be more effective than apomorphine in improving erectile function, with higher efficacy rates (73-88%) compared to placebo (26-32%) 1

The National Comprehensive Cancer Network recommends PDE-5 inhibitors (sildenafil, vardenafil, tadalafil, mirodenafil, and udenafil) as first-line pharmacological treatments for erectile dysfunction, with high efficacy rates (73-88%) compared to placebo (26-32%) 1, 2
Vibratory therapy may improve problems with orgasm intensity or achievement, and PDE-5 inhibitors can also be used for problems with male orgasms (less intensity, difficulty achieving) 3, 5
For ejaculation issues, the Journal of Urology recommends SSRIs (paroxetine, sertraline, citalopram, fluoxetine) dosed daily or clomipramine dosed on-demand, and pelvic physical therapy may help with various sexual function issues 3, 6, 7

Lifestyle modifications (smoking cessation, weight loss, increased physical activity, reduced alcohol consumption) can improve sexual function, and treatment of underlying psychosocial problems and referral to sex and couples therapy when appropriate can alleviate symptoms of sexual dysfunction 3, 5