Treatment of IgA Vasculitis with Organ Involvement

Adjunctive Therapies and Prophylaxis

• The American College of Rheumatology recommends pneumocystis prophylaxis with trimethoprim-sulfamethoxazole for all patients receiving cyclophosphamide, as well as bone protection with calcium, vitamin D, and bisphosphonates for all patients on glucocorticoids 1
• The European League Against Rheumatism suggests the use of mesna with cyclophosphamide to prevent hemorrhagic cystitis, and antiemetics routinely with IV cyclophosphamide 2

Refractory Disease Options

• The American College of Rheumatology recommends intravenous immunoglobulin (IVIG) as an option for patients not responding to initial therapy, with a dose of 2 g/kg over 5 days for persistent low-level activity 1