Adderall XR to Vyvanse Conversion Guideline

Introduction to Conversion

• The American College of Obstetricians and Gynecologists recommends starting with Vyvanse 50mg once daily in the morning when switching from Adderall XR 30mg, representing a conservative 1:1.67 conversion ratio that accounts for the prodrug metabolism 1, 2

Practical Conversion Algorithm

• Morning administration of Vyvanse is critical to minimize sleep disturbances, with a recommended duration of at least one week to evaluate response before making any dose adjustments, based on guidelines from the American Journal of Obstetrics and Gynecology 3, 4
• The conversion should be done with caution, allowing for titration to assess tolerability, and increasing by 10mg weekly increments up to the maximum of 70mg daily, as recommended by the American Journal of Obstetrics and Gynecology 1, 2

Monitoring Requirements Post-Conversion

• Systematic monitoring is essential after switching medications, including assessing blood pressure and pulse at the first follow-up visit, evaluating target ADHD symptoms using standardized rating scales, and weighing the patient at each visit to detect appetite suppression, as recommended by Praxis Medical Insights 3, 5

Titration After Conversion

• If symptom control is inadequate after one week on Vyvanse 50mg, the dose can be increased by 10mg weekly increments up to the maximum of 70mg daily, but not exceeding the FDA-approved maximum dose, as recommended by the American Journal of Obstetrics and Gynecology 1, 2