Maximum Dose of Maltofer (Iron Polymaltose)

Dosing Recommendations

The maximum recommended dose of Maltofer (iron polymaltose) is 100 mg of elemental iron once daily for adults with iron deficiency anemia, as recommended by the British Society of Gastroenterology 1, 2
For treatment of iron deficiency anemia in adults, 50-100 mg of elemental iron once daily is the recommended dose, according to the British Society of Gastroenterology 1, 2
For patients with moderate iron deficiency anemia, ferric maltol (Maltofer) at 30 mg twice daily (60 mg total elemental iron per day) has been shown to be effective, as stated by the British Society of Gastroenterology 3, 4
Higher doses (200 mg elemental iron per day) may be used in specific conditions such as chronic kidney disease, but this is not the standard recommendation for most patients, as suggested by the American Society of Nephrology 5

Recent evidence suggests that once-daily dosing is preferred over multiple daily doses, with short-term studies showing that oral doses of 60 mg elemental iron stimulate hepcidin levels, reducing subsequent iron absorption by 35-45%, according to the British Society of Gastroenterology 1, 2, 3
The overall absorption of iron from 60 mg elemental iron taken once daily was similar to that from 60 mg taken twice daily, as reported by the British Society of Gastroenterology 3
For patients experiencing gastrointestinal side effects, alternate-day dosing may be considered, as it leads to significantly increased fractional iron absorption in iron-depleted individuals, as stated by the British Society of Gastroenterology 1

Regular monitoring of hemoglobin is recommended to ensure a satisfactory response, approximately every 4 weeks until hemoglobin normalizes, as suggested by the British Society of Gastroenterology 2
After normalization of hemoglobin, oral iron should be continued for 2-3 months to replenish iron stores, according to the British Society of Gastroenterology 2
The absence of a hemoglobin rise of at least 10 g/L after 2 weeks of daily oral iron therapy strongly predicts subsequent failure to achieve a sustained response, as reported by the British Society of Gastroenterology 1