Guidelines for Oral Ketorolac Use in Pain Management

Clinical Applications and Contraindications

For moderate pain, NSAIDs like ketorolac can be considered as part of a pain management strategy, according to the National Comprehensive Cancer Network 1, 2
Avoid using oral ketorolac in patients with active peptic ulcer disease, GI bleeding, aspirin/NSAID-induced asthma, pregnancy, or cerebrovascular hemorrhage, as recommended by medical guidelines 3
Use oral ketorolac with caution in patients aged 60 years or older, those with compromised fluid status, interstitial nephritis, papillary necrosis, or those on concomitant nephrotoxic drugs, as advised by medical guidelines 3

Monitor baseline blood pressure, kidney function, liver function tests, complete blood count, and fecal occult blood, and repeat these tests every 3 months for long-term therapy, as recommended by medical guidelines 3
Oral ketorolac 20 mg taken 40-60 minutes before a procedure may reduce pain during and after the procedure, such as IUD placement, according to the American Journal of Obstetrics and Gynecology 4