CPK Elevation with Nexlizet

Incidence and Magnitude of CPK Elevation

• The American College of Cardiology notes that bempedoic acid has lower muscle-related adverse effects compared to statins, with CPK elevations occurring at lower rates 1, 2

Clinical Significance and Safety Profile

• Bempedoic acid is activated only in the liver, explaining the reduced muscle toxicity compared to statins, and has low rates of muscle-related adverse effects in statin-intolerant patients 1, 2, 3
• The American College of Cardiology guidelines specifically note that bempedoic acid has "low rates of muscle-related adverse effects" 3

Important Clinical Context

• The American College of Cardiology and American Heart Association recommend bempedoic acid as a preferred option for statin-intolerant patients requiring additional LDL-C lowering 3
• Bempedoic acid is particularly valuable for statin-intolerant patients who often discontinue therapy due to muscle symptoms, with a muscle-sparing effect that makes it a key advantage over statins 3, 4
• Other adverse effects, such as gout, liver enzyme elevations, and tendon rupture, may be more clinically relevant than CPK elevation with bempedoic acid 1, 2, 3