Bridging with Oral Aripiprazole for Dose Increase

Dosing and Monitoring Recommendations

• Continue oral supplementation until the next scheduled IM injection, at which point the IM dose can be increased, as recommended by the medical community 1
• Antipsychotic polypharmacy, combining oral and injectable forms of the same medication, is appropriate in clinical scenarios where rapid dose adjustment is needed, according to medical guidelines 1, 2
• This approach allows for maintaining therapeutic levels while avoiding the risks of abrupt dose changes, with a strength of evidence supporting its effectiveness 2
• Assess for potential side effects including headache, agitation, anxiety, insomnia, dizziness, and drowsiness, as reported in medical literature 3
• Do not discontinue the current IM regimen abruptly while initiating oral supplementation, to ensure continuous therapeutic coverage, as advised by medical experts 1, 2

Rationale and Important Considerations

• The bridging strategy allows for prompt intervention while maintaining the benefits of long-acting injectable therapy, with the goal of optimizing symptom control and quality of life for the patient, as supported by medical evidence 1, 2