Ziprasidone Administration and Safety Considerations

Efficacy and Administration

• Intramuscular ziprasidone (20 mg) is effective for rapid reduction of acute agitation with onset of action within 15 minutes, as recommended by the American College of Emergency Physicians 1, 2

Cardiac Considerations

• Ziprasidone should be avoided in patients at significant risk for torsades de pointes, including those with baseline QT prolongation, concomitant QT-prolonging medications, or history of this arrhythmia, according to the American Heart Association 3, 4

Contraindications and Precautions

• The American College of Cardiology recommends avoiding ziprasidone in patients with recent acute myocardial infarction 1