Ureaplasma Screening Recommendations

Introduction to Ureaplasma

The Infectious Diseases Society of America recommends against routine testing for Ureaplasma urealyticum in asymptomatic individuals due to the high prevalence of colonization in asymptomatic, sexually active people 1
Current guidelines do not recommend routine testing for Ureaplasma urealyticum in asymptomatic individuals, as stated by the Infectious Diseases Society of America 1

Treating asymptomatic bacteriuria (including Ureaplasma) is generally not recommended due to concerns about antibiotic resistance, as suggested by The Journal of Urology and Clinical Infectious Diseases 2, 3
Unnecessary antibiotic use contributes to the pressing concerns of antibiotic resistance and contradicts principles of antibiotic stewardship, according to The Journal of Urology 2

The Centers for Disease Control and Prevention recommends targeting Chlamydia trachomatis as the primary cause of Non-gonococcal Urethritis (NGU), while Ureaplasma urealyticum is implicated in 20-40% of NGU cases, as stated in MMWR Recommendations and Reports 4, 5
In asymptomatic individuals with neurogenic lower urinary tract dysfunction, guidelines explicitly recommend against surveillance/screening urine testing, including cultures that might detect Ureaplasma, as recommended by The Journal of Urology 2