5-Fluorouracil Eye Drops for Ocular Surface Squamous Neoplasia

Primary Indication

• Ocular surface squamous neoplasia (OSSN) is the main indication for 5-FU eye drops, as confirmed by multiple ophthalmology guidelines 1
• 5-FU is one of several topical chemotherapeutic agents that can be used either as primary therapy or as adjunctive treatment following surgical excision of OSSN 1

Treatment Considerations

• 5-FU is particularly useful for patients where tissue preservation is important 1

Clinical Pearls

• DPD (dihydropyrimidine dehydrogenase) testing should be considered before initiating 5-FU treatment to identify patients at risk for systemic toxicity 2
• For patients with partial DPD deficiency, alternative treatments should be considered, or if 5-FU must be used, smaller areas should be treated with close monitoring 2