Toxoplasmosis Treatment Guidelines

Current Treatment Recommendations

The American College of Physicians recommends pyrimethamine plus sulfadiazine with folinic acid as the standard treatment for confirmed toxoplasmosis 3
The Centers for Disease Control and Prevention suggests trimethoprim-sulfamethoxazole as an alternative treatment option, particularly in combination with spiramycin 3

The Centers for Disease Control and Prevention recommends ivermectin for scabies treatment at a dose of 200μg/kg orally, repeated in 2 weeks 4
Ivermectin is indicated for pediculosis pubis (pubic lice) at a dose of 250μg/kg repeated in 2 weeks 5, 6
The World Health Organization recommends ivermectin for strongyloides stercoralis infection 3
Ivermectin is used to treat cutaneous larva migrans at a dose of 200μg/kg as a single dose 7
Onchocerciasis treatment is done with ivermectin at 200μg/kg monthly for 3 months 7

The National Institutes of Health states that ivermectin is considered to have "human data suggest low risk" in pregnancy and is probably compatible with breastfeeding 8, 4
Very low levels of ivermectin are excreted into breast milk, making it likely compatible with breastfeeding 1
Ivermectin should be taken with food because bioavailability is increased, thereby increasing penetration of the drug 4
The Centers for Disease Control and Prevention warns that ivermectin has limited ovicidal activity and may not prevent recurrences from eggs at the time of treatment, necessitating repeat dosing 4
Dose adjustments are not required in patients with renal impairment, but the safety of multiple doses in patients with severe liver disease is not known 4