Optimal Administration of Lansoprazole and Sucralfate

Medication Administration Guidelines

• Standard dosing of sucralfate is typically 1 g four times daily (before meals and at bedtime) 1
• The American College of Cardiology recommends PPIs like lansoprazole as the preferred agents for therapy and prophylaxis of NSAID and ASA-associated GI injury 2
• Sucralfate has been shown to be effective in treating NSAID-associated duodenal ulcers but is not effective for gastric ulcers, according to the American College of Cardiology 3
• The American College of Cardiology Foundation notes that sucralfate's use is not recommended for NSAID-related gastric ulcers because of the availability of superior alternatives like PPIs 3

Stress Ulcer Prophylaxis

• For patients taking both medications for stress ulcer prophylaxis, PPIs have been proven superior to both ranitidine and misoprostol in preventing NSAID ulcer recurrence 3