Guideline Recommendations for Adding Ezetimibe in Statin‑Intolerant or High‑LDL‑C Patients

American Heart Association / American Stroke Association Guidance

• The American Heart Association and American Stroke Association state that ezetimibe may be considered for patients who are unable to achieve LDL‑C targets with statin therapy or who have documented statin intolerance; however, the impact of ezetimibe on reducing cardiovascular events has not been definitively established. 1

ACC/AHA 2018 Recommendation

• The 2018 ACC/AHA guideline assigns a Class IIa recommendation (reasonable to add) for ezetimibe in adults with clinical atherosclerotic cardiovascular disease (ASCVD) who are already on the maximally tolerated statin dose and have an LDL‑C ≥ 70 mg/dL. 2