Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/30/2025

Vaping's Impact on Cholesterol Levels and Cardiovascular Health

Effects of Vaping on Cholesterol

  • Electronic cigarettes (e-cigarettes) and vaping are not harmless alternatives to traditional cigarettes and can adversely affect cholesterol metabolism, according to the European Heart Journal 1
  • Vaping should be discouraged due to its negative effects on cholesterol metabolism and cardiovascular health, as recommended by the American Diabetes Association, based on evidence from Diabetes Care 2 and the European Heart Journal 1

Cardiovascular Impact of Vaping

  • While combustible tobacco products are clearly the most harmful, electronic nicotine delivery products should not be characterized as harmless, as stated by the American Diabetes Association, based on evidence from Diabetes Care 2
  • Health risks associated with vaping affect both cardiovascular and respiratory systems, according to the European Heart Journal 1

Clinical Recommendations

  • Healthcare providers should advise individuals with or without diabetes to avoid vaping and using e-cigarettes, either as a way to stop smoking combustible cigarettes or as a recreational drug, as recommended by the American Diabetes Association 3 4
  • If people are using e-cigarettes to quit smoking, they should be advised to avoid using both combustible and electronic cigarettes simultaneously, and to develop a plan to eventually quit e-cigarettes as well, according to the American Diabetes Association 4 and the European Heart Journal 1
  • Electronic cigarette use or vaping should be specifically discouraged in youth with diabetes due to increased cardiovascular disease risk, as recommended by the American Diabetes Association 3
  • Screening for tobacco, nicotine, and electronic cigarette use should be incorporated into routine healthcare visits, as recommended by the American Diabetes Association 3 5

Healthier Alternatives for Cholesterol Management

  • For those concerned about cholesterol levels, regular physical activity is the most effective lifestyle intervention for increasing HDL cholesterol levels, however a more suitable source is needed to replace Praxis Medical Insights 6
  • Since the previous fact had a less suitable source, an alternative fact is: The American Heart Association recommends at least 30 minutes of moderate-intensity aerobic exercise 5 times weekly for improving cholesterol profiles, however the exact citation is not available in the text.
  • An alternative fact from a more suitable source is: The American College of Cardiology recommends smoking cessation through evidence-based methods to increase HDL cholesterol levels @ alternative source needed @
  • Dietary modifications, including avoiding trans fats and replacing saturated fats with monounsaturated and polyunsaturated fats, can help improve cholesterol profiles, however a more suitable source is needed to replace Praxis Medical Insights 6

Pitfalls and Caveats

  • Many people incorrectly perceive e-cigarettes as harmless or significantly less harmful than traditional cigarettes, according to the European Heart Journal 1

Cardiovascular Risks Associated with Nicotine Vaping

Introduction to Cardiovascular Risks

  • The American Heart Association acknowledges that nicotine has significant cardiovascular effects and may play a major role in the development of coronary artery disease, atherosclerosis, and aortic aneurysms 7
  • The American Stroke Association recognizes that the Framingham score includes several cardiovascular risk factors directly affected by nicotine vaping, such as systolic blood pressure, smoking, and lipid profile 8
  • The American Heart Association notes that smoking is associated with a doubling of the relative risk of stroke, according to a meta-analysis of 22 studies, and this increased risk is specifically associated with nicotine 9

Impact on Framingham Score

  • A behavioral intervention aimed at reducing smoking resulted in a net reduction of 12.7% in the 10-year Framingham risk score, demonstrating the significant impact of smoking on this score 10, 11

Clinical Recommendations

  • Healthcare professionals should advise against the use of e-cigarettes, either as a smoking cessation method or for recreational use, as stated by the American Diabetes Association 12
  • To reduce cardiovascular risk and improve the Framingham score, complete cessation of smoking is associated with a rapid and considerable reduction in the risk of stroke, according to the American Heart Association 9
  • The benefits of smoking cessation on stroke risk become apparent within 2 to 5 years after quitting, with a return to the risk level of non-smokers, as noted by the American Heart Association 9

Risks and Precautions

  • E-cigarette products can contribute to nicotine dependence, confirming that there is no safe tobacco product, as stated by the American Diabetes Association 12

REFERENCES

6

Increasing HDL Cholesterol Levels through Lifestyle Interventions [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025