Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 10/26/2025

Management of FET Cycle with Thin Endometrium on Progynova

Progesterone Initiation Protocol

  • The American Society for Reproductive Medicine recommends beginning progesterone supplementation only after achieving target endometrial thickness of ≥7 mm, according to the Human Reproduction Update 1
  • The Human Reproduction Update suggests using vaginal progesterone for luteal phase support in artificial FET cycles, and beginning progesterone supplementation on the day of endometrial transformation 1
  • The guideline recommends continuing estrogen and progesterone at original doses for 3-4 weeks after positive pregnancy test, then gradually reducing dosage to complete discontinuation within 2 weeks, as stated in the Human Reproduction Update 1