Ceftazidime and Ceftazidime-Avibactam Therapeutic Applications

Clinical Uses and Recommendations

• The Infectious Diseases Society of America recommends ceftazidime-avibactam for the treatment of complicated urinary tract infections caused by carbapenem-resistant Enterobacteriaceae (CRE) 1, 2
• Ceftazidime-avibactam is recommended for hospital-acquired pneumonia, including ventilator-associated infections, by the European Society of Clinical Microbiology and Infectious Diseases 1, 2
• Ceftazidime is used for the treatment of intra-abdominal infections, as suggested by the Surgical Infection Society 3, 4
• Resistance to ceftazidime-avibactam has been reported in KPC-producing Klebsiella pneumoniae, which is a concern for treatment of carbapenem-resistant infections, according to the Clinical Microbiology and Infection society 2, 5