Nitrofurantoin Use in Pregnancy

Trimester-Specific Recommendations

• The European Respiratory Society guidelines classify nitrofurantoin as "possibly safe" during the first trimester 1

Critical Clinical Considerations

• The European Respiratory Society guidelines suggest that nitrofurantoin should be avoided at delivery due to risk of neonatal hyperbilirubinemia and hemolytic anemia, similar to sulfonamides 1