Psilocybin Mushrooms and Fertility

Evidence on Fertility Risks

The European Society for Medical Oncology (ESMO) guidelines extensively catalog substances and treatments that affect fertility, including chemotherapy agents, radiation therapy, targeted therapies, and immunotherapy, but psilocybin is not mentioned 1, 2, 3, 4
The American Urological Association (AUA) and the American Society for Reproductive Medicine (ASRM) guidelines emphasize that male infertility counseling should address known gonadotoxic medications, such as cyclophosphamide and anabolic steroids, but psilocybin is not included 5, 6
The World Health Organization (WHO) guidelines acknowledge that data on most lifestyle and environmental factors affecting fertility remain limited and require further study, including the impact of recreational drug use on fertility 6
The ESMO guidelines detail that ovarian toxicity occurs with alkylating agents, radiation, and some targeted agents, but psilocybin is not mentioned as having any impact on ovarian reserve, follicle development, or hormonal function 1, 3, 4
The absence of evidence on psilocybin and fertility reflects limited research rather than proven safety, according to the Human Reproduction Update 6

The AUA guidelines recommend that male infertility counseling should address lifestyle factors with documented but limited evidence, such as smoking and obesity, but psilocybin is not included 6, 5
The ESMO guidelines state that psilocybin is not mentioned as having any impact on ovarian reserve, follicle development, or hormonal function, and is not included in the list of substances that affect fertility 1, 3, 4
The ASCO guidelines do not mention psilocybin as a substance that affects fertility, despite cataloging agents with "unknown risk" 1, 3, 4