Dosing of Intravenous Doxycycline in Patients with Acute Kidney Injury

Special Considerations in AKI Patients

• The Kidney International recommends considering temporary discontinuation of other potentially nephrotoxic medications during doxycycline therapy to prevent further kidney injury in patients with acute kidney injury (AKI) 1, 2

Monitoring Recommendations

• The American Journal of Transplantation suggests regular assessment of kidney function during therapy is prudent, though specific dose adjustments are not required in patients with AKI 3
• The Kidney International recommends assessing for drug interactions with other medications that may be prescribed for AKI management 2