Testosterone Level Monitoring Guidelines

Target Testosterone Levels and Monitoring Schedule

• The goal is to achieve total testosterone levels in the middle tertile of the normal reference range (450-600 ng/dL) 1
• After achieving stable therapeutic levels, testosterone should be measured every 6-12 months while on therapy 2, 3, 4
• Ongoing monitoring ensures maintenance of therapeutic testosterone levels 2, 3
• Ongoing monitoring ensures early detection of supraphysiologic levels that could increase adverse event risk 1
• Therapy should be discontinued if target levels are achieved without symptom improvement after 3-6 months 2, 3, 4

Critical Timing Considerations

• Morning timing is essential due to diurnal variation in testosterone levels 5