Baclofen Side Effects in Alcohol Use Disorders

Serious Side Effects and Special Considerations

• Impaired mentation is a significant concern, particularly in patients with advanced liver disease or hepatic encephalopathy, according to the American Association for the Study of Liver Diseases 1, 2
• Baclofen is the only AUD pharmacotherapy tested in a randomized controlled trial specifically in patients with alcoholic cirrhosis, as noted by the American Association for the Study of Liver Diseases 1, 2

Dosing and Monitoring

• Standard dosing for alcohol use disorders ranges from 30-60 mg/day, as recommended by the American Association for the Study of Liver Diseases 1
• Careful monitoring is required when initiating baclofen, particularly in patients with advanced liver disease, according to the American Association for the Study of Liver Diseases 1, 2