Cefazolin Dosing Guidelines for Specific Infections

Pediatric and Adult Dosing Intervals

• For staphylococcal infections (including methicillin-susceptible S. aureus) in pediatric patients: 150 mg/kg/day divided every 8 hours, as recommended by the Infectious Diseases Society of America 1, 2
• For infective endocarditis in pediatric patients: 100 mg/kg/day IV divided every 8 hours (maximum 12 g daily), according to the American Heart Association 3, 4

CNS Infections

• For CNS infections, maintain the every 8-hour interval even at high doses (100 mg/kg/day) to ensure adequate penetration, as suggested by medical guidelines 5