Dehydration-Induced Leukocytosis

Clinical Evidence and Management

• Rehydration may help normalize white blood cell counts in dehydrated patients, as recommended by the American Diabetes Association 1
• Intravenous hydration (2.5-3 liters/m²/day) is recommended for patients with hyperleukocytosis, particularly in conditions like leukemia, as suggested by the European Leukemia Society 2, 3
• Patients with hyperleukocytosis due to conditions like leukemia should receive aggressive hydration as part of their initial management, according to the American Society of Hematology 2, 4