Diagnostic Criteria for Hyperparathyroidism

Urinary Calcium Excretion

• Normal 24-hour urinary calcium excretion is typically <250 mg/day (6.2 mmol/day) in females, and <4 mg/kg/day (0.1 mmol/kg/day) for all adults, according to the Nature Reviews Nephrology guidelines 2
• The 24-hour urine collection should be performed on a random diet, and proper acidification of the urine sample is necessary to prevent calcium precipitation, as recommended by The Journal of Urology and Nature Reviews Nephrology guidelines 1, 3

Collection Methodology

• The collection should be analyzed for total volume, calcium, creatinine, and other parameters like sodium and oxalate, as suggested by The Journal of Urology guidelines 1
• Creatinine measurement is essential to verify the completeness of the collection, according to The Journal of Urology guidelines 1, 4