Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/25/2025

Atrophic Gastritis and Hashimoto's Thyroiditis Association

Introduction to the Association

  • Atrophic gastritis is strongly associated with Hashimoto's thyroiditis, with up to one-third of patients with autoimmune thyroid disease having autoimmune gastritis, as noted by the American Gastroenterological Association 1, 2

Epidemiological Evidence

  • Approximately one-third of patients with autoimmune thyroid disease have autoimmune gastritis, according to the American Gastroenterological Association 1

Clinical Implications

  • Patients with autoimmune gastritis should be screened for autoimmune thyroid disease due to this strong association, as recommended by the American Gastroenterological Association 5, 6
  • Micronutrient deficiencies, particularly iron and vitamin B12, can occur due to this co-occurrence, as reported by the American Gastroenterological Association 4, 5

Diagnostic Considerations

  • In patients with Hashimoto's thyroiditis who have unexplained iron or vitamin B12 deficiency, atrophic gastritis should be considered, as suggested by the American Gastroenterological Association 5

Management Recommendations

  • Patients with autoimmune gastritis should undergo screening for autoimmune thyroid disease, as recommended by the American Gastroenterological Association 1, 7
  • Evaluation for iron and vitamin B12 deficiencies should be performed in patients with atrophic gastritis, especially if corpus-predominant, as recommended by the American Gastroenterological Association 1

Potential Complications to Monitor

  • Gastric neuroendocrine tumors are more common in patients with autoimmune gastritis, as reported by the American Gastroenterological Association 4, 6
  • Gastric adenocarcinoma risk is increased in patients with severe atrophic gastritis, as noted by the American Gastroenterological Association 4, 8