Bupropion's Sexual Profile

Comparative Studies with Other Antidepressants

• Bupropion has significantly lower rates of sexual adverse events than fluoxetine or sertraline, according to the American College of Physicians guidelines 1, 2
• Paroxetine has the highest rates of sexual dysfunction among antidepressants, exceeding fluoxetine, fluvoxamine, nefazodone, and sertraline, as noted by the American College of Physicians 1, 2

Contrast with SSRIs

• SSRIs typically cause decreased libido, orgasmic dysfunction, and erectile problems, as reported by the American Urological Association 3, 4
• Sexual dysfunction rates with SSRIs are likely underreported in clinical trials, according to the American College of Physicians 1, 2

Important Caveat

• The American College of Physicians acknowledges that while bupropion carries a slightly increased seizure risk, this must be weighed against its superior sexual side effect profile 1, 2