Multifocal Acquired Demyelinating Sensory and Motor Neuropathy (MADSAM) Characteristics

Clinical Presentation and Diagnosis

• The MADSAM variant of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is characterized by preserved reflexes in areas not affected by weakness, unlike typical CIDP where reflexes are generally reduced or absent throughout, according to the American Academy of Neurology 1
• Nerve biopsy may be particularly useful in evaluating atypical forms of CIDP like MADSAM, as these variants may have distinctive pathological features, as suggested by the European Academy of Neurology 2
• MRI of the brachial or lumbosacral plexus can help identify focal or diffuse peripheral nerve abnormalities in CIDP variants, as recommended by the American College of Radiology 3