Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 11/4/2025

Management of Neurogenic Shock in Spinal Cord Injury

Initial Management

  • Maintain mean arterial pressure (MAP) at 85-90 mmHg using vasopressors combined with fluid resuscitation to ensure adequate spinal cord perfusion and prevent secondary injury, as recommended by the American College of Surgeons 1, 2

Spinal Immobilization

  • Immediately immobilize the spine of any patient with suspected spinal cord injury to prevent onset or worsening of neurological deficit, according to the American Association of Neurological Surgeons 3, 4
  • Use rigid cervical collar with head-neck-chest stabilization for transport, as suggested by the American College of Emergency Physicians 3
  • Apply manual in-line stabilization (MILS) during any airway manipulation, as recommended by the American Society of Anesthesiologists 3, 4

Airway Management

  • Perform rapid sequence intubation using direct laryngoscopy with gum elastic bougie while maintaining cervical spine alignment, as recommended by the American Society of Anesthesiologists 3, 4
  • Remove the anterior portion of the cervical collar during intubation to improve mouth opening and glottic exposure while maintaining MILS, according to the American College of Emergency Physicians 3, 4
  • Avoid Sellick maneuver to minimize cervical spine movement, as suggested by the American Association of Neurological Surgeons 3, 4
  • Succinylcholine can be safely used within the first 48 hours post-injury; after 48 hours, use rocuronium to avoid hyperkalemia risk, as recommended by the American Society of Anesthesiologists 5

Hemodynamic Resuscitation

  • Target MAP of 85-90 mmHg to maintain spinal cord perfusion and reduce secondary ischemic injury, according to the American College of Surgeons 1, 2
  • This target should be maintained for at least 5-7 days post-injury, as recommended by the American Association of Neurological Surgeons 1, 2
  • Use blood products rather than excessive crystalloids to avoid fluid overload, as suggested by the American College of Surgeons 1

Monitoring Requirements

  • Continuous hemodynamic monitoring with arterial line for accurate MAP measurement, as recommended by the American College of Surgeons 1, 2
  • Hourly vital signs and neurological assessments, according to the American Association of Neurological Surgeons 1, 2