Prazosin Dosage and Treatment Guidelines

Introduction to Prazosin Treatment

• Prazosin is considered a fourth-line agent in hypertension treatment algorithms, typically added after other medications have failed to achieve target blood pressure, according to the American Heart Association 1, 2

Monitoring and Dosage Adjustment

• Monitor for orthostatic hypotension, especially when initiating therapy or increasing the dose, as recommended by the American College of Cardiology 3
• Assess blood pressure control within 3 months of treatment changes, as suggested by the American Heart Association 4
• If blood pressure remains uncontrolled despite optimal dosing, consider referral to a hypertension specialist, as recommended by the American Society of Hypertension 5