Pneumococcal and Influenza Vaccination Guidelines

Pneumococcal Vaccine Recommendations

The Centers for Disease Control and Prevention (CDC) recommends that adults ≥65 years of age with no previous pneumococcal vaccination receive a single dose of PCV20 1, 2
For adults ≥65 years of age previously vaccinated with PPSV23 only, the CDC recommends administering a single dose of PCV20 at least 1 year after the last PPSV23 dose 1, 2
The CDC suggests an alternative schedule for adults ≥65 years of age if PCV20 is unavailable: administer PCV15, followed by PPSV23 at least 1 year later 3, 4
For adults 19-64 years with immunocompromising conditions and no previous pneumococcal vaccination, the CDC recommends administering a single dose of PCV20 4, 5
For adults 19-64 years with chronic medical conditions and no previous pneumococcal vaccination, the CDC recommends administering a single dose of PCV20 3, 1
Hematopoietic Stem Cell Transplant (HSCT) recipients should receive 3 doses of PCV20, 4 weeks apart starting 3-6 months after HSCT, followed by a fourth PCV20 dose at least 6 months after the third dose or at least 12 months after HSCT, whichever is later 1, 2

Pneumococcal and influenza vaccines can be administered at the same visit at different anatomic sites 1
For patients who have received PCV15 but have not completed their series with PPSV23, one dose of PCV20 may be used if PPSV23 is not available 1, 2
Failing to check the patient's prior pneumococcal vaccination history can lead to incorrect vaccination schedules 1, 2
Not waiting the recommended interval between different pneumococcal vaccines (typically ≥1 year after PCV13 or ≥1 year after PPSV23) can lead to reduced immune response 1, 2
Withholding vaccination in the absence of an immunization record is not recommended; the patient's verbal history should be used to determine prior vaccination status 2

Adults with asplenia, complement deficiencies, or who work in outbreak settings are considered at increased risk for meningococcal disease and should receive appropriate meningococcal vaccination 6