Daptomycin's Clinical Applications and Limitations

Important Limitations and Dosing Considerations

• Daptomycin is not indicated for pneumonia due to inactivation by pulmonary surfactant, as recommended by the Infectious Diseases Society of America 1
• The optimal dosing for adults with complicated skin and skin structure infections is 4-6 mg/kg once daily, and higher doses (8-10 mg/kg) may be considered for complicated infections including bacteremia, according to the World Society of Emergency Surgery and the Infectious Diseases Society of America 2, 3