Lamotrigine Monitoring Guidelines

Introduction to Monitoring Approaches

• The consensus from therapeutic drug monitoring guidelines is that lamotrigine levels need not be routinely measured, as the clinical evidence does not support routine use of serum concentrations for dose adjustment 1

Clinical Considerations for Dose Adjustment

• Dose titration should be based on clinical response and tolerability, monitoring for therapeutic efficacy and watching for adverse effects, particularly rash during initial titration 1
• Adjust dosing based on concomitant medications: reduce dose with valproate, increase dose with enzyme-inducing anticonvulsants 1