Monitoring Levetiracetam Levels in Specific Clinical Scenarios

Introduction to Levetiracetam Monitoring

• Routine therapeutic drug monitoring of levetiracetam is generally not recommended due to its predictable pharmacokinetics, broad therapeutic window, and lack of established correlation between serum levels and efficacy or toxicity, as stated by the National Comprehensive Cancer Network 1

Clinical Scenarios Requiring Monitoring

• Patients receiving CAR T-cell therapy with CNS disease or history of seizures may require levetiracetam monitoring, as suggested by guidelines from oncology experts 2, 3