Neurological Effects on Hormone Regulation

Introduction to Hormonal Changes

• The hypothalamic-pituitary axis is directly affected, leading to alterations in hormone metabolism and changes in peripheral endocrine glands, according to the American Academy of Neurology and the Endocrine Society 1
• Reproductive hormone alterations occur, as reported by the Endocrine Society 1
• Phenytoin therapy is associated with several effects on hormone regulation, including:
• Long-term phenytoin therapy is associated with alterations in reproductive hormonal function through its enzyme-inducing properties, as stated by the American College of Clinical Pharmacology and supported by the American Academy of Neurology and the Endocrine Society 1