Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 10/19/2025

Risk of DVT in Pancreatitis

Critical Mortality Impact

  • VTE is the second leading cause of death in cancer patients after the malignancy itself, with pancreatic cancer ranking among the highest VTE risk malignancies 1, 2

Pancreatic Cancer Context

  • Primary prophylaxis with LMWH or direct oral anticoagulants is strongly recommended for locally advanced or metastatic pancreatic cancer patients receiving chemotherapy, according to the American Society of Clinical Oncology 3, 5
  • Prophylaxis reduces VTE risk by 69-85% in pancreatic cancer patients, as recommended by the European Society for Medical Oncology 3, 4
  • The number needed to treat is 5-11 patients to prevent one VTE event, as suggested by the American Society of Clinical Oncology and the European Society for Medical Oncology 4, 6

REFERENCES

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