Ursodeoxycholic Acid and Triglycerides

Evidência de Diretrizes sobre UDCA e Lipídios

• The American Association for the Study of Liver Diseases (AASLD) clearly states that UDCA is not recommended for the specific treatment of NAFLD or NASH, and does not identify hypertriglyceridemia as an adverse effect 1
• The Korean Association for the Study of the Liver also confirms that UDCA has not demonstrated efficacy in the treatment of NASH in controlled studies, without mentioning elevated triglycerides as a concern 2

Contexto Clínico Importante

• The American Heart Association/American College of Cardiology identifies medications that genuinely elevate triglycerides, including atypical antipsychotics, beta-blockers, thiazides, corticosteroids, bile acid sequestrants, and rosiglitazone, but UDCA is not included in this list 3
• It is crucial not to confuse UDCA with bile acid sequestrants (such as cholestyramine or colestipol), which can cause elevated triglycerides and require monitoring 4