EpiPen Dosing Guidelines

Weight-Based Dosing

• The American Academy of Pediatrics recommends using 0.15 mg dose for children weighing less than 30 kg, administered as 0.01 mg/kg up to a maximum of 0.3 mg 1
• For adults and children weighing 30 kg or more, the recommended dose is 0.3 mg, administered as 0.3 to 0.5 mg 1

Administration Technique

• The administration site and technique remain constant for all ages, with injection into the anterolateral aspect of the mid-thigh (vastus lateralis muscle) 2
• This achieves peak plasma concentrations in 8±2 minutes, compared to 34±14 minutes with subcutaneous deltoid injection 3
• The dose can be administered through clothing if necessary, and repeated every 5-10 minutes as needed if symptoms persist or worsen 3

Prescription Guidelines

• The guideline society recommends prescribing two autoinjectors of the appropriate dose, as approximately 10-20% of patients require more than one dose 3